• 汕頭大學醫(yī)學院第二附屬醫(yī)院器官移植中心（汕頭515041）;

目的  探討豬-猴異種血管移植超急性排斥反應(yīng)（HAR）的機理。
方法  豬股靜脈原位異種移植于恒河猴，發(fā)生HAR后通過免疫組化檢測移植血管IgG、IgM、C3及C4的沉積。
結(jié)果  大量IgM、C3和C4沉積于移植靜脈內(nèi)皮，未發(fā)現(xiàn)IgG沉積于移植血管內(nèi)皮。
結(jié)論  豬-猴異種移植HAR是由異種自然抗體IgM與異抗原特異結(jié)合啟動，進而以經(jīng)典途徑激活補體系統(tǒng)而發(fā)生。

引用本文： 文軍,陳耿臻,沈文律. 豬-猴異種血管移植免疫反應(yīng)初探. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(4): 218-219. doi: 復制

版權(quán)信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  2. 2. Mckenzin IFC, Xing PX, Vaughan HA, et al. Distribution of the major xenoantigen (gal α 1,3gal) for pig to human xenografts 〔Ｊ〕. Transplant Immunology, 1994; 2∶81.
  3. 3. Lawson JH, Platt JL. Molecular barriers to xenotransplantation〔Ｊ〕. Transplantation, 1996; 62(2)∶303.
  4. 4. Miyagawa S, Hirose H, Shirakura R, et al. The mechanism of discordant xenograft rejection 〔Ｊ〕. Transplantation, 1988; 46(3)∶825.
  5. 5. Dalmasso AP, Vercellotti GM, Fishel RJ, et al. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients 〔Ｊ〕. Am Pathology, 1992; 140(6)∶1157.
  6. 6. Zhao Z, Termignon JL, Cardoso J, et al. Hyperacute xenograft rejection in the swinetohuman donorrecipient combination 〔Ｊ〕. Transplantation, 1994; 57(2)∶245.