為研究胃大部切除術(shù)后殘胃粘膜屏障損傷與殘胃粘膜癌前病變的關(guān)系，在甲基硝基亞硝基胍(N-methy-N’-nitro-Nnitrosoguanidine,MNNG)誘發(fā)犬殘胃粘膜癌前病變過程中，胃鏡下定期行殘胃粘膜活檢的同時(shí)，對(duì)跨胃粘膜電位差(gastric transmucosal potential difference, GTPD)及粘膜細(xì)胞核DNA含量進(jìn)行了動(dòng)態(tài)測(cè)定。結(jié)果：隨著殘胃吻合口粘膜病變加重，GTPD值呈漸進(jìn)性下降趨勢(shì)，且GTPD值與相應(yīng)粘膜細(xì)胞核DNA含量之間呈顯著負(fù)相關(guān)關(guān)系。本實(shí)驗(yàn)結(jié)果提示：隨著殘胃粘膜屏障損傷程度的加重，粘膜組織細(xì)胞惡變潛能就越大；殘胃粘膜屏障損傷在殘胃癌前病變發(fā)生過程中起著至關(guān)重要的作用。
引用本文： 湯禮軍,田伏洲,麻曉林,周丁華,晏才杰. 殘胃粘膜屏障損傷與殘胃癌前病變關(guān)系的實(shí)驗(yàn)研究. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(1): 7-10. doi: 復(fù)制
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- 1. Takeuchi. Clinical study on gastric mucosal blood flow and potential difference. Gastroenterological Endoscope, 1987; 29(5)∶845.
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- 3. Morris CP, Hoei L, Yelson K, et al. Correlation between changes in indicators of gastric mucosal barrier integrity at time of exposure to “barrier breaker” and extent of hemorrhagic erosions one hour later. Dig Dis Sci, 1984; 29(1)∶6.
- 4. Goddard PJ, Lenard DM. In vitro recovery of canine gastric mucosal surface hydrophobicity and potential difference after aspirin damage. Dig Dis Sci, 1995; 40(6)∶1357.
- 5. Sorbye H, Pieol HY, Scot LE, et al. Gastric carcinogenesis in rats given hypertonic salt at different times before a single dose of MNNG. J Cancer Res Clin Oncol, 1994; 120(120)∶159.
- 6. Hiraki Y. Experimental study of the effect of bile juice on the remnant gastric cancer development. Hippon Geka Gakkai Zasshi, 1991; 92(6)∶645.
- 7. 湯禮軍， 晏才杰， 麻曉林等. MNNG誘發(fā)犬殘胃粘膜癌前病變組織中MG7Ag表達(dá)的動(dòng)態(tài)定量研究. 胃腸病學(xué)和肝病學(xué)雜志， 1996； 5(1)∶32.
- 8. Imai T, Moit L, Soue H,et al. Reduction of cell proliferative activities of gastric stump adenomatous hyperplasias after bile reflux diversion in rats. Carcinogenesis, 1993; 14(23)∶1765.
- 9. Tanigawa N, Masuda Y, Shimo T, et al. Thymidine uptake in vitro as a prognostic indicator for primary gastric cancer. Cancer, 1993; 72(10)∶2883.
- 10. Fisher SG, Davis F, Nelson R, et al. A cohort study of stomach cancer risk in men after gastric surgery for benign disease. J Natl Cancer Inst, 1993; 85(16)∶1303.