• 南京醫(yī)科大學(xué)第一附屬醫(yī)院普外科(南京210029);

本實(shí)驗(yàn)應(yīng)用電子自旋共振(ESR)技術(shù)及自旋捕捉劑PBN直接測(cè)定肝硬變門脈高壓(PHT)大鼠胃粘膜在休克再灌注前后及應(yīng)用超氧化物歧化酶(SOD)、丹參(RSM)治療后氧自由基(OFR)的動(dòng)態(tài)變化，同時(shí)檢測(cè)胃粘膜中SOD活性，并觀察同期胃粘膜的光鏡、電鏡病理改變。結(jié)果：PHT胃粘膜在休克再灌注過程中有大量OFR產(chǎn)生，粘膜損傷的嚴(yán)重程度與OFR含量及SOD活性密切相關(guān)；PHT胃粘膜更易受休克再灌注時(shí)OFR的損傷，早期應(yīng)用抗氧化劑SOD及RSM，可通過不同機(jī)理減輕胃粘膜再灌注損傷。

引用本文： 徐澤寬,張?？? 肝硬變門脈高壓休克再灌注胃粘膜損傷的實(shí)驗(yàn)研究. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(5): 267-269. doi: 復(fù)制

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  2. 2. Kirk AP, Dooley JS, Hunt RH. Peptic ulceration in patients with chronic liver disease. Dig Dis Sci, 1980; 25(10)∶756.
  3. 3. Lai EK, Crossley C, Sridhar R, et al. In vivo spin trapping of free redicals generated in brain, spleen, and liver during radiation of mice. Arch Biochem Biophy, 1986; 244(1)∶156.
  4. 4. Kuppusamy P, Zweier JL. Characterization of free radical generation by xanthine oxidase. J Biolchem, 1989; 264(17)∶9880.
  5. 5. Zweier JL, Flaherty JT, Weisfeldt ML. Direct measurement of free radical generation following reperfusion ischemia myocardium. Med Sci, 1987; 84(5)∶1404.
  6. 6. Sarfeh IJ, Tarnawski A. Increased susceptibility of the portal hypertensive gastric mucosa to damage. J Clin Gastroenterol, 1991; 13(Suppl 1)∶S18.
  7. 7. Perry MA, Wadhwa S, Parks DA, et al. Role of oxygen radicals in ischemiainduced lesions in the cat stomach. Am J Physiol, 1988; 254(3)∶366.
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