對(duì)18例結(jié)直腸癌患者采用實(shí)體瘤短期體外懸浮細(xì)胞培養(yǎng)法進(jìn)行染色體分析。結(jié)果：染色體結(jié)構(gòu)重排涉及17p、5q、6q（78%、61%、50%），染色體增加頻率最高的是7號(hào)、3號(hào)（72%、66%），丟失則最常見(jiàn)于17號(hào)、5號(hào)、18號(hào)（50%、44%、33%）。大量標(biāo)記染色體、雙微體及超倍體核型預(yù)示腫瘤易早期復(fù)發(fā)和轉(zhuǎn)移。此結(jié)果提示：17號(hào)、5號(hào)及18號(hào)染色體畸變與結(jié)直腸癌發(fā)生發(fā)展有密切關(guān)系。非隨機(jī)性染色體異常的多樣性和復(fù)雜性更表明大腸癌的發(fā)生是多基因多步驟演變的結(jié)果。
引用本文： 李立,嚴(yán)律南,吳言濤,汪林,周宏遠(yuǎn). 結(jié)直腸癌非隨機(jī)性染色體異常的研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 1996, 3(4): 193-195. doi: 復(fù)制
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- 4. Alan W.Biochemical markers for colorectal cancer.Surg Clin Nor Am,1993;73:1.
- 5. Wang LM,Patel V,Ghosh L,et al.Mutation in the nm23 gene is associated with metastasis in colorectal cancar.Cancer Res,1993;53:717.
- 6. Ookawak,Sakamoto M,Hirohashi S,et al.Concordant p53 and Dcc alterations and allelic losses on chromosomes 17p and 18q associated with liver metastasis of colorectal carcinomas.Int J Cancer,1993;53:382.
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