• 1.華西醫(yī)科大學附屬第一醫(yī)院普外科(成都610041)2.北京醫(yī)科大學附一院內科3.華西醫(yī)科大學腫瘤研究所;

對18例結直腸癌患者采用實體瘤短期體外懸浮細胞培養(yǎng)法進行染色體分析。結果：染色體結構重排涉及17p、5q、6q（78%、61%、50%），染色體增加頻率最高的是7號、3號（72%、66%），丟失則最常見于17號、5號、18號（50%、44%、33%）。大量標記染色體、雙微體及超倍體核型預示腫瘤易早期復發(fā)和轉移。此結果提示：17號、5號及18號染色體畸變與結直腸癌發(fā)生發(fā)展有密切關系。非隨機性染色體異常的多樣性和復雜性更表明大腸癌的發(fā)生是多基因多步驟演變的結果。

引用本文： 李立,嚴律南,吳言濤,汪林,周宏遠. 結直腸癌非隨機性染色體異常的研究. 中國普外基礎與臨床雜志, 1996, 3(4): 193-195. doi: 復制

版權信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎與臨床雜志》版權所有，未經授權不得轉載、改編

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  1. 1. Delattre O,Law DJ,Remuikos Y,et al.Multiple genetic alterations in distal and proximal colorectal cancer.Lancet,1989;2:353.
  2. 2. Muleris M,Salmon RJ,Dutrillaux B.Cytogenetics of colorectal adenocarcinomas.Cancer Genet Cytogenet,1990;46:143.
  3. 3. 邱紅明.遺傳性非息肉病性大腸癌分子病理學研究進展.國外醫(yī)學遺傳學分冊,1995;4:176.
  4. 4. Alan W.Biochemical markers for colorectal cancer.Surg Clin Nor Am,1993;73:1.
  5. 5. Wang LM,Patel V,Ghosh L,et al.Mutation in the nm23 gene is associated with metastasis in colorectal cancar.Cancer Res,1993;53:717.
  6. 6. Ookawak,Sakamoto M,Hirohashi S,et al.Concordant p53 and Dcc alterations and allelic losses on chromosomes 17p and 18q associated with liver metastasis of colorectal carcinomas.Int J Cancer,1993;53:382.
  7. 7. Marx J.A challenge to p16 gene as a major tumor suppressor.Science,1994;264:1846.