• 浙江醫(yī)科大學附屬第一醫(yī)院外科 ( 杭州 310003);

采用ABC免疫組織化學方法對41例胃癌組織，66例正常胃和良性病變胃組織內癌胚抗原表達作了研究。結果顯示：胃癌組織內癌胚抗原(CEA)的表達程度明顯強于正常胃和良性病變胃組織；前者CEA的分布形式多呈胞漿型和間質型，而后者則呈腔緣型和膜型。同時表明組織內CEA的分布形式與腫瘤細胞的生長方式和浸潤深度有關。作者認為組織內CEA的表達狀況與胃癌細胞生物學行為有關，其在組織內的分布形式較其含量更為重要，相同組織學類型CEA亦可有不同的分布形式。

引用本文： 梁廷波,鄭樹森,孫義國,于吉人,林建燦. 癌胚抗原的表達與胃癌細胞生物學行為的關系研究. 中國普外基礎與臨床雜志, 1996, 3(3): 156-159. doi: 復制

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1. 徐光煒.胃癌.第1版.北京：人民衛(wèi)生出版社，1987：289～300.
2. Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
3. Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
4. Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
5. Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
6. 張蔭昌.胃病理及胃黏膜活檢.第1版.沈陽：遼寧科學技術出版社，1988：82.
7. Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
8. Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
9. Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
10. Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
11. Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
12. Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
13. Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.
  1. 1. 徐光煒.胃癌.第1版.北京：人民衛(wèi)生出版社，1987：289～300.
  2. 2. Kojima O, Ikeda E, Uehara Y,et al. Correlation between CEA in gastric cancer tissue and survival of patient with gastric cancer .Gann, 1984；75(3) :230.
  3. 3. Wiggers T,Arends JW, Verstijnen C,et al. Prognostic signigicance of CEA immunoreactivity patterns in large bowel carcinoma tissue .Br J Cancer, 1986；54(3) :409.
  4. 4. Davidson BR,Sams VR,Styles J,et al. Comparative study of carcinoembryonic antigen and epithelial membrane anti gen expression in normal colon,adenomas and adenocarcinomas of the colon and rectum .Gut, 1989；30(9) :1260.
  5. 5. Hamada Y, Yamamura M, Hioki K, et al. Immunohistochemical study of CEA in patients with colonreetal cancer: correlation with plasma CEA levels .Cancer, 1985； 55(1) :137.
  6. 6. 張蔭昌.胃病理及胃黏膜活檢.第1版.沈陽：遼寧科學技術出版社，1988：82.
  7. 7. Motoyamao T, Watanabe H. CEA production in human gastric cancer lines in vitro and in nude mice .Gann, 1983； 74(5) :679.
  8. 8. Nagura H, Tsutsumi Y, Shioda Y, et al. Immunohistochemistry of carcinomas and associated diseases Novel distribution of CEA and secretory complement in the surface of gastric cancer cells .J Histo Cyto, 1983；31(1A) :193.
  9. 9. Kiyama T,0nda M,Tokunaga A,et al. Changes in serum and tissue CEA with growth of human gastric cancer xenograft in nude mice .Jap J Can Res, 1990； 81(1) :58.
  10. 10. Kiyama T. Serum CEA levels in patients with gastric carcinoma correlate with the tumorigenicity of their xenograft in nude mice .Jap J Surg, 1991； 21(1) :32.
  11. 11. Jessup JM, Giavazzi R, Campbell D,et al. Growth potential of human colonrectal carcinoma in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients .Cancer Res, 1988；48(6) :1689.
  12. 12. Benchinol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen,a human tumor marker, functions as an intercel luar adhension molecule .Cell, 1989； 57(2) :327.
  13. 13. Pignatelli M,Durbin H,Bodmer WF. Carcinomembryonic antigen functions as an accessory adhension molecule mediating colon epithelial cell-collagen interaction .Pro Natl Acad Sci, 1990；87(4) :1541.