• 四川大學(xué)華西第二醫(yī)院婦產(chǎn)科（成都，610041）;

【摘要】　 乙醛脫氫酶（acetaldehyde dehydrogenase，ALDH）廣泛存在于不同組織中，是一類具有高度氧化活性的胞漿酶類。隨著腫瘤干細(xì)胞理論的提出，ALHD1被發(fā)現(xiàn)為多種腫瘤干細(xì)胞的表面標(biāo)志，在腫瘤的診斷、治療、判斷預(yù)后等方面發(fā)揮一定作用?，F(xiàn)就ALDH1在不同腫瘤的具體作用及在放化療耐藥方面的機(jī)制作一綜述。

引用本文： 萬琪,王飛,陳亞麗,鄭艾. 乙醛脫氫酶1與腫瘤干細(xì)胞相關(guān)性研究. 華西醫(yī)學(xué), 2011, 26(3): 476-478. doi: 復(fù)制

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1. 　Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome[J]. Cell Stem Cell, 2007,1(5): 555-567.
2. 　Su Y, Qiu Q, Zhang XQ, et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer[J]. Cancer Epidem Biomar, 2010,19(2): 327-337.
3. 　Jiang F, Qiu Q, Khanna A, et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer[J]. Mol Cancer Res, 2009, 7(3): 330-338.
4. 　Chang B, Liu GZ, Xue FX, et al. ALDH1 expression correlates with favorable prognosis in ovarian cancers[J]. Modern Pathol, 2009, 22(6): 817-823.
5. 　Gupta PB, Chaffer CL, Weinberg RA. Cancer stem cells: mirage or reality? [J]. Nat Med, 2009, 15(9): 1010-1012.
6. 　Douville J, Beaulieu R, Balicki D. ALDH1 as a functional marker of cancer stem and progenitor cells[J]. Stem Cell Dev, 2009, 18(1): 17-25.
7. 　Li CW, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells[J]. Cancer Res, 2007, 67(3): 1030-1037.
8. 　Corti S, Locatelli F, Papadimitriou D, et al. Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity[J]. Stem Cells, 2006, 24(4): 975-985.
9. 　Hu L, Wen JM, Sham JST, et al. Establishment of cell lines from a primary hepatocellular carcinoma and its metastatis[J]. Cancer Genet Cytogen, 2004, 148(1): 80-84.
10. 　Patrawala L, Calhoun-Davis T, Schneider-Broussard R, et al. Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44(+)alpha 2 beta 1(+) cell population is enriched in tumor-initiating cells[J]. Cancer Res, 2007, 67(14): 6796-6805.
11. 　Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells[J]. Proc Natl Acad Sci USA, 2007, 104(24): 10158-10163.
12. 　Bar EE, Chaudhry A, Lin A, Fan X, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma[J]. Stem Cells, 2007, 25(10): 2524-2533.
13. 　Seigel GM, Campbell LM, Narayan M, et al. Cancer stem cell characteristics in retinoblastoma[J]. Mol Vis, 2005, 11(86-87): 729-737.
14. 　Ma S, Chan KW, Lee TKW, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations[J]. Mol Cancer Res, 2008, 6(7): 1146-1153.
15. 　周凌, 虞佩, 王建豐,等. 乙醛脫氫酶1蛋白在乳腺癌中的表達(dá)及臨床意義[J]. 腫瘤, 2009, 29(7): 663-667.
16. 　Dragani TA, Falvella FS, Manenti G, et al. Downexpression of aldehyde dehydrogenase 1 in murine lung tumors[J]. Mol Carcinogen, 1996, 16(3): 123-125.
17. 　Chen YC, Chen YW, Hsu HS, et al. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer[J]. Biochem Bioph Res, 2009, 385(3): 307-313.
18. 　Moreb JS, Zucali JR, Ostmark B, et al. Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by aldefluor flow cytometry-based assay[J]. Cytom Part B-Clin Cy, 2007, 72B(4): 281-289.
19. 　Jelski W, Zalewski B, Chrostek L, et al. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer[J]. Clin Exp Med, 2007, 7(4): 154-157.
20. 　Honoki K, Fujii H, Kubo A, et al. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance[J]. Oncol Rep, 2010, 24(2): 501-505.
  1. 1. 　Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome[J]. Cell Stem Cell, 2007,1(5): 555-567.
  2. 2. 　Su Y, Qiu Q, Zhang XQ, et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer[J]. Cancer Epidem Biomar, 2010,19(2): 327-337.
  3. 3. 　Jiang F, Qiu Q, Khanna A, et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer[J]. Mol Cancer Res, 2009, 7(3): 330-338.
  4. 4. 　Chang B, Liu GZ, Xue FX, et al. ALDH1 expression correlates with favorable prognosis in ovarian cancers[J]. Modern Pathol, 2009, 22(6): 817-823.
  5. 5. 　Gupta PB, Chaffer CL, Weinberg RA. Cancer stem cells: mirage or reality? [J]. Nat Med, 2009, 15(9): 1010-1012.
  6. 6. 　Douville J, Beaulieu R, Balicki D. ALDH1 as a functional marker of cancer stem and progenitor cells[J]. Stem Cell Dev, 2009, 18(1): 17-25.
  7. 7. 　Li CW, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells[J]. Cancer Res, 2007, 67(3): 1030-1037.
  8. 8. 　Corti S, Locatelli F, Papadimitriou D, et al. Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity[J]. Stem Cells, 2006, 24(4): 975-985.
  9. 9. 　Hu L, Wen JM, Sham JST, et al. Establishment of cell lines from a primary hepatocellular carcinoma and its metastatis[J]. Cancer Genet Cytogen, 2004, 148(1): 80-84.
  10. 10. 　Patrawala L, Calhoun-Davis T, Schneider-Broussard R, et al. Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44(+)alpha 2 beta 1(+) cell population is enriched in tumor-initiating cells[J]. Cancer Res, 2007, 67(14): 6796-6805.
  11. 11. 　Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells[J]. Proc Natl Acad Sci USA, 2007, 104(24): 10158-10163.
  12. 12. 　Bar EE, Chaudhry A, Lin A, Fan X, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma[J]. Stem Cells, 2007, 25(10): 2524-2533.
  13. 13. 　Seigel GM, Campbell LM, Narayan M, et al. Cancer stem cell characteristics in retinoblastoma[J]. Mol Vis, 2005, 11(86-87): 729-737.
  14. 14. 　Ma S, Chan KW, Lee TKW, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations[J]. Mol Cancer Res, 2008, 6(7): 1146-1153.
  15. 15. 　周凌, 虞佩, 王建豐,等. 乙醛脫氫酶1蛋白在乳腺癌中的表達(dá)及臨床意義[J]. 腫瘤, 2009, 29(7): 663-667.
  16. 16. 　Dragani TA, Falvella FS, Manenti G, et al. Downexpression of aldehyde dehydrogenase 1 in murine lung tumors[J]. Mol Carcinogen, 1996, 16(3): 123-125.
  17. 17. 　Chen YC, Chen YW, Hsu HS, et al. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer[J]. Biochem Bioph Res, 2009, 385(3): 307-313.
  18. 18. 　Moreb JS, Zucali JR, Ostmark B, et al. Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by aldefluor flow cytometry-based assay[J]. Cytom Part B-Clin Cy, 2007, 72B(4): 281-289.
  19. 19. 　Jelski W, Zalewski B, Chrostek L, et al. Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer[J]. Clin Exp Med, 2007, 7(4): 154-157.
  20. 20. 　Honoki K, Fujii H, Kubo A, et al. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance[J]. Oncol Rep, 2010, 24(2): 501-505.