【摘要】 目的 觀察人類免疫缺陷病毒（HIV）感染后對人體各個系統(tǒng)的影響，為其診斷和治療提供經驗。 方法 回顧性分析2005年1月—2010年6月于華西醫(yī)院確診為HIV感染13例患者的臨床表現和相關實驗室指標。 結果 13例HIV感染患者均合并其他感染，以結核病最為常見；除有T淋巴細胞異常外，多數患者可合并出現血液學異常，包括貧血、白細胞和血小板降低；生化異常，包括球蛋白升高、白蛋白降低；HIV感染患者可合并出現風濕病癥狀和免疫學異常。 結論 HIV感染患者臨床表現復雜多樣，可合并出現多種感染和風濕病癥狀，血液學及免疫學異常也比較常見。
【Abstract】 Objective To observe the impact of human immunodeficiency virus (HIV) on each system of human body after its infection, in order to provide experiences for diagnosis and treatment of this disease. Methods The clinical manifestations and related laboratory results of 13 inpatients treated in West China Hospital of Sichuan University from January 2005 to June 2010 were reviewed retrospectively. Results The incidence of infection in these patients was 100% with tuberculosis as the most common infection. Apart from the abnormality of T lymphocytes, most patients had a change of hematology and biochemistry, including anemia, depression of leucocytes and platelets, hyperglobulinemia and hypoproteinemia; HIV-infected patients may also presented with rheumatic manifestations or abnormality in the immune system. Conclusion The clinical manifestations of patients with AIDS are complicated. Many kinds of infections and rheumatic manifestations may merge and the change in hematology and immunology is common.
引用本文： 李莉,劉鋼. 人類免疫缺陷病毒感染患者臨床特點分析. 華西醫(yī)學, 2011, 26(6): 874-877. doi: 復制
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| 2. | 王少儉, 李勝洋. 122例艾滋病機會性感染臨床分析[J]. 河南預防醫(yī)學雜志, 2010, 21(2): 93-96. |
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| 4. | Olayemi E, Awodu OA, Bazuaye GN. Autoimmune hemolytic anemia in HIV-infected patients: a hospital based study[J]. Ann Afr Med, 2008, 7(2): 72-76. |
| 5. | 潘光合, 譚勇, 吳文旺, 等. 出入境人群HIVg感染者/AIDS患者血清生化指標分析[J]. 旅行醫(yī)學科學, 2009, 15(2): 4-7. |
| 6. | 張自華, 張群智, 孔山. 129例HIV感染者血清蛋白分析[J]. 海南醫(yī)學, 2010, 21(3): 93-94. |
| 7. | 譚琳, 謝瑜, 周摯. 艾滋病患者 CD4+細胞計數與外周血細胞計數關系的研究[J]. 臨床薈萃, 2009, 24(5): 396-398. |
| 8. | Sarcletti M, Bitterlich W, Fuchs D, et al. Is the poorer rate of survival among patients with human immunodeficiency virus infection and anemia linked to immune activation?[J]. J Infect Dis, 2002, 186(1): 141-142. |
| 9. | Russo S, Lopalco L. Is autoimmunity a component of natural immunity to HIV?[J]. Curr HIV Res, 2006, 4(2): 177-190. |
| 10. | Root-Bernstein R, Rallo A. Antigenic complementarity resulting in idiotype-antiidiotype immune complexes: possible contributor to AIDS pathogenesis and autoimmunity[J]. Autoimmunity, 2004, 37(3): 203-210. |
| 11. | Rynes RI. HIV and rheumatologic autoimmune phenomena: imitator or illuminator[J]. Clin Exp Rheumatol, 1990, 8(2): 103-106. |
| 12. | 劉德純. 艾滋病臨床病理學[M]. 合肥:安徽科學技術出版社, 2002: 1140-1141. |
| 13. | Kulthanan K, Jiamton S, Omcharoen V, et al. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients[J]. Int J Dermatol, 2002, 41(7): 417-422. |
| 14. | Reveille JD, Williams FM. Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection[J]. Best Pract Res Clin Rheumatol, 2006, 20(6): 1159-1179. |
| 15. | Cuellar ML. HIV infection-associated inflammatory musculoskeletal disorders[J]. Rheum Dis Clin North Am, 1998, 24(2): 403-421. |
| 16. | Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)[J]. Ann Intern Med, 1989, 111(2): 158-167. |
- 1. 劉春云, 成培金, 廖遠, 等. 2005-2008年興文縣HIV-AIDS流行病學分析[J]. 預防醫(yī)學情報雜志, 2009, 25(8): 677-678.
- 2. 王少儉, 李勝洋. 122例艾滋病機會性感染臨床分析[J]. 河南預防醫(yī)學雜志, 2010, 21(2): 93-96.
- 3. 張興權, 范江. 艾滋病毒感染與艾滋病[M]. 北京:人民衛(wèi)生出版社, 1999: 173-230.
- 4. Olayemi E, Awodu OA, Bazuaye GN. Autoimmune hemolytic anemia in HIV-infected patients: a hospital based study[J]. Ann Afr Med, 2008, 7(2): 72-76.
- 5. 潘光合, 譚勇, 吳文旺, 等. 出入境人群HIVg感染者/AIDS患者血清生化指標分析[J]. 旅行醫(yī)學科學, 2009, 15(2): 4-7.
- 6. 張自華, 張群智, 孔山. 129例HIV感染者血清蛋白分析[J]. 海南醫(yī)學, 2010, 21(3): 93-94.
- 7. 譚琳, 謝瑜, 周摯. 艾滋病患者 CD4+細胞計數與外周血細胞計數關系的研究[J]. 臨床薈萃, 2009, 24(5): 396-398.
- 8. Sarcletti M, Bitterlich W, Fuchs D, et al. Is the poorer rate of survival among patients with human immunodeficiency virus infection and anemia linked to immune activation?[J]. J Infect Dis, 2002, 186(1): 141-142.
- 9. Russo S, Lopalco L. Is autoimmunity a component of natural immunity to HIV?[J]. Curr HIV Res, 2006, 4(2): 177-190.
- 10. Root-Bernstein R, Rallo A. Antigenic complementarity resulting in idiotype-antiidiotype immune complexes: possible contributor to AIDS pathogenesis and autoimmunity[J]. Autoimmunity, 2004, 37(3): 203-210.
- 11. Rynes RI. HIV and rheumatologic autoimmune phenomena: imitator or illuminator[J]. Clin Exp Rheumatol, 1990, 8(2): 103-106.
- 12. 劉德純. 艾滋病臨床病理學[M]. 合肥:安徽科學技術出版社, 2002: 1140-1141.
- 13. Kulthanan K, Jiamton S, Omcharoen V, et al. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients[J]. Int J Dermatol, 2002, 41(7): 417-422.
- 14. Reveille JD, Williams FM. Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection[J]. Best Pract Res Clin Rheumatol, 2006, 20(6): 1159-1179.
- 15. Cuellar ML. HIV infection-associated inflammatory musculoskeletal disorders[J]. Rheum Dis Clin North Am, 1998, 24(2): 403-421.
- 16. Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)[J]. Ann Intern Med, 1989, 111(2): 158-167.