摘要:目的:分析高膽紅素血癥新生兒血清神經(jīng)元特異性烯醇化酶(NSE)含量和新生兒行為神經(jīng)能力測評(Neonatal Behavioral Neurological Assessment,NBNA)的變化,探討高膽紅素血癥新生兒血清NSE含量變化的臨床意義。方法:應(yīng)用放射免疫分析法分別測定60例高膽紅素血癥新生兒和20例對照組新生兒血清NSE含量,同步測定血清總膽紅素(TSB),進(jìn)行NBNA評分;高膽紅素血癥組早期干預(yù)后再次測定血清NSE含量。結(jié)果: 與對照組比較,高膽紅素血癥新生兒血清TSB、NSE含量顯著升高,而NBNA評分明顯降低,差異有顯著性意義(P lt;0.01);對照組與高膽紅素血癥新生兒輕度增高、中度增高、重度增高四組兩兩比較(均P lt;0.05),存在顯著性差異;血清NSE含量與NBNA評分呈明顯負(fù)相關(guān)(r=-0628,P lt;0.01);高膽紅素血癥新生兒經(jīng)早期干預(yù)治療后,血清NSE含量均下降(P lt;0.05),差異有顯著性。結(jié)論: 高膽紅素血癥可導(dǎo)致新生兒腦損傷,血清NSE含量可以作為腦損傷的監(jiān)測指標(biāo)。
Abstract: Objective: To analyze levels of neuronspecific enolase(NSE)in serum and neonatal behavioral neurological assessment (NBNA), to study whether NSE in serum can be used as a tool for the early identification of brain damage in neonatal hyperbilirubinemia. Methods: Serum NSE level of 60 full term infants with hyperbilirubinemia and 20 cases as to control group were measured by radioimmunoassay; Also total serum bilirubin (TSB) and NBNA were detected. In the hyperbilirubinemia group,serum NSE level were measured second when TSB were less than 855 μmol/L(5 mg/dL). Results: Compared with control group,the levels of serum TSB、NSE of the hyperbilirubinemia group were significantly higher, but NBNA score was significantly lower. The levels of serum NSE was significantly negative related to NBNA score. In the hyperbilirubinemia group, serum NSE level were significantly lower after treatment. Conclusion: Hyperbilirubinemia in neonates can cause brain damage. Serum NSE level could work as monitoring indexes of this damage.

引用本文： 劉輝,朱紅巖,茆康衛(wèi),王海峰,蘇海燕. 高膽紅素血癥新生兒血清神經(jīng)元特異性烯醇化酶的變化及臨床意義. 華西醫(yī)學(xué), 2009, 24(11): 2890-2891. doi: 復(fù)制