• 1.蘭州軍區(qū)烏魯木齊總醫(yī)院普外科(烏魯木齊830000);;
  • 2.蘭州軍區(qū)烏魯木齊總醫(yī)院病理科((烏魯木齊830000);;
  • 3.第四軍醫(yī)大學(xué)唐都醫(yī)院(西安710038);

目的  探討p16和p53蛋白在膽囊癌發(fā)生、發(fā)展中的作用及其相關(guān)性。
方法  應(yīng)用免疫組化法對40例膽囊癌組織中p16和p53蛋白的表達(dá)情況進(jìn)行檢測。
結(jié)果  p16和p53蛋白的表達(dá)與膽囊癌的組織學(xué)分化，淋巴結(jié)轉(zhuǎn)移以及預(yù)后相關(guān)； p16蛋白的表達(dá)還與臨床分期有關(guān)。結(jié)論 p16蛋白的失表達(dá)是發(fā)生在膽囊癌發(fā)展的晚期階段，認(rèn)為p16和p53蛋白的表達(dá)有助于原發(fā)性膽囊癌的分化及其預(yù)后的判斷。

引用本文： 張東,馮德元,王平,鄒賽英,何澤生. 抑癌基因p16和p53在原發(fā)性膽囊癌中的表達(dá)及其相關(guān)性的初步研究. 中國普外基礎(chǔ)與臨床雜志, 2000, 7(2): 85-86. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  1. 1. Caldas C, Hahn SA, Da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma 〔Ｊ〕. Nature Genet, 1994; 8(1)∶27.
  2. 2. Walker DG, Duan W, Popovic EA, et al. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas 〔Ｊ〕. Cancer Res, 1995; 55(1)∶20.
  3. 3. Fujimoto K, Yamada Y, Okajima E, et al. Frequent association of p53 gene mutation in invasive bladder cancer 〔Ｊ〕. Cancer Res, 1992; 52(6)∶1393.
  4. 4. Rigaudy P, Echhart W. Nucleotide sequence of a CDNA encoding the monkey cellular phosphoprotein p53 〔Ｊ〕. Nucleic Acids Res, 1989; 17(20)∶8375.